Double Blind Randomised Control Trial on the effects of Creatine Monohydrate. (Currently Closed)

Bioenergetic anomalies contribute to the development of depressive symptoms in both MDD and bipolar 
illness, according to findings from epidemiology, genetics, biochemistry, and neuroimaging (BD). They 
propose that substances like creatine, which may improve brain energy storage, might aid in the treatment of 
depression.
Many clinical disorders linked to decreased energy storage and bioenergetics synthesis are also linked to 
depression. Depression is common in those who have a chronic medical condition, such as type 1 or type 2 diabetes. Depression is three times as common in type 1 diabetes patients than in the general population, and 
twice as common in type 2 diabetes patients. Similarly, type 1 diabetes is linked to alterations in energy 
metabolism, and mitochondrial function is important in the treatment and prevention of the disorder's longterm implications. According to the PCr/ATP ratio, brain energy metabolism is aberrant in type 1 diabetes, 
according to case-control research. In addition, research using phosphorus-31 magnetic resonance 
spectroscopy (31P MRS) in the heart revealed disturbed energy balance and lower PCr/ATP ratios in type 1 
diabetes patients, which matched the pattern seen in the brain. In certain studies, dietary habits that lower 
creatine consumption are linked to an increased risk of depression, while the results are equivocal. Elderly 
men who ate a vegetarian diet had a greater risk of depression, more severe symptoms of depression, and 
higher Geriatric Depression Scale scores, according to Li and colleagues, while this was not the case for 
women.